Carrie Anne Horarik, 46, and Carol Amsbury Jackson, 77, both of Clearlake, were the victims of the wreck, according to Lt. Corey Paulich.
The California Highway Patrol said the fatal collision occurred on Highway 29 south of Grange Road shortly before 10:30 p.m. Saturday, as Lake County News has reported.
The CHP stated in its initial report that Horarik was driving a 2011 Nissan Sentra southbound when she crossed over the highway’s solid double yellow lines.
Horarik traveled directly into the path of Jackson, who was driving a 1999 Ford Ranger northbound, resulting in the head-on wreck, the CHP said.
Both Horarik and Jackson died at the scene, officials said.
The CHP said the crash’s cause remains under investigation.
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