The California Highway Patrol confirmed the death, which also was reported from the scene by firefighters shortly before midnight.
The solo-vehicle crash occurred shortly before 11:30 p.m. Sunday on Highway 20 near New Long Valley Road, based on CHP report.
Two people were reported to be in the vehicle, which had major damage and was blocking the highway's eastbound lane, according to the CHP.
Northshore Fire and Cal Fire responded, with units arriving at the scene requesting an air ambulance to transport an individual with major injuries, based on radio traffic.
Over the scanner firefighters also requested a ground ambulance for one person with minor to moderate injuries.
Shortly after 11:50 p.m., incident command canceled the air ambulance and reported they were working to revive the seriously injured patient, who was reported to be the passenger.
A short time later officials confirmed the person had died, with firefighters requesting the Lake County Sheriff's Office send a coroner to respond.
Information about the cause of the wreck was not immediately available early Monday.
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