The crash occurred on Lakeshore Boulevard at Rainbow Road shortly before noon on Sunday, according to radio traffic and the California Highway Patrol’s online incident logs.
Reports from the scene said there were two vehicles involved, with a male unresponsive in one of them.
Firefighters worked to save the individual, who was determined to have died shortly afterward.
The Lakeport Fire chief handed over the scene to the CHP shortly after 12:15 p.m.
Additional information was not immediately available from the CHP on Sunday.
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